In the event that I have to switch folders, I open xlights , change the folder. Close xlights.
Then open it again (it is now pointing to the new folder), then I look for and open a sequence.
To go back to the first folder , I save what I am doing , close xl.
Then open xl gain , change folders and close xl
etc ie I do not try and 'in flight' change folders and then continue on to do stuff. Because then at the end , when xl prompts to save stuff , I would not expect it to save in the right folder.
A bit cautious maybe , but I spent several weeks doing this during the manual documentation and managed without issues due to the swapping.