Let's assume you have a pixel string on a gutter that will be 55 lighted pixels.
and, the distance from the controller to "first pixel" is long enough to need one or more Null Pixels.
If you configure the controller to have 3 null pixels, it will actually send 58 pixels worth of data on the output, but the first 3 will always be Zero so that they stay dark. Since pixel cost runs from $0.25 to $0.50 each, this can be pretty economical if you are willing to cut and splice to get the distance.
The other option is to use Corey's uAmp device. It serves the same purpose as a Null Pixel (extending the distance to First Pixel) but your software and hardware don't know or care that it is there. (i.e., it works with any 3-wire protocol pixel strings - just solder it in line). A single uAmp can usually carry you 30feet or more with good wiring. Maybe 100ft with better wire or Coax.