No. All programs, commercial and otherwise (including xLights), had text too small to read when I tried to put it at 100%. When I put it back at the "recommended" 250%, all the programs were easy to read.
From time to time one of the popups in xLights will come up as a very small text, but that is the exception at this time and not my main focus. It is moving props on the layout screen that takes a bit of manipulation.