I've seen Sean post advertised limits for the LOR USB dongle and it was based on how many channels you could run without getting lag. If those are 25 sixteen channel controller that's 400 channels and you probably have lag already if using the USB dongle even if you are running with LOR software. Or maybe you've already done what I did when I was using only LOR software which is I had to run 2 dongles to reduce the lag. When I switched it all to DMX the lag problems disappeared. I've never run my show from xLights. When I switched to DMX it was the same time I switched to using the FPP and I ran all E1.31 with a single wire going out to my yard to a 5 port switch. Then just use one of the many E1.31 cards that has a DMX output, create a DMX to LOR crossover cable for the first LOR controller and then daisy chain from there like normal.
The problem is most people are afraid to change everything once they have something working. What I did was waited till the day after Christmas 2 years ago and I switched everything over to the FPP and E1.31 data all in one day. I was willing to take the risk that last week but wanted to test while everything was still up in the yard. It worked so beautiful and I didn't touch the FPP for a week.