I talked to Dave on the phone to understand the issue a bit more. In V3, there was a global variable on the e1.31 outputs for whether a channel data has changed. If ANY e1.31 channel changed, all of the e1.31 universes were output. In V4, I moved it to a per-universe flag so universes that don't have any changes don't get output. This can reduce the amount of network traffic quite a bit. However, the etherdongle apparently doesn't output anything until it receives the data for all of it's universes. Thus, the optimization breaks that.
I'll see what can be done to work around this. I'm kind of thinking the "Enable" flag we have on the setup tab may become more of a tri-state of "No", "On Changes", "Always" or similar. Gotta think about it some more.