Ive done them both ways out of xlights. Being that I only have 6 LOR boards with no intentions to buy anymore "best laid plans of mice and men" I just left them on the LOR usb 484. If you have more than 6 LOR controllers you will want to run them in DMX mode.
Just make a simple LOR to DMX crossover cable and get a e1.31 to DMX bridge like the J1sys D2 or DIYLED expresses or the older RPM model etc.
That setup would look like this............
