Maybe do a Tools -> Package Sequence, post the zip file and let someone here take a look.
If you start xLights from a command prompt with the /w option it resets to defaults. (Backup your show folder first and you might need to repoint to the show folder after).
Hit the X on all those panels and see if anything is under there. The grid should not be able to be moved it just sizes itself around the panels.
In the future it would be good to save yourself a Perspective when you get the panels arranged how you like so you can always recall that perspective when things get messed up. You could even try deleting the Perspectives section from the xlights_rgbeffects.xml and start xLights it will recreate it.